Colorectal Cancer is On the Rise- Beware!
Did you know that globally, colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths? In 2020, over 1.9 million new CRC cases and 930,000 deaths due to CRC were reported. By 2040, the incidence of CRC is estimated to increase by 63%, reaching 3.2 million new cases per year, with a 73% rise in mortality, leading to 1.6 million deaths annually [1]. In 2018, Asia had the highest proportions of both incident (51.8%) and mortality (52.4%) CRC cases, comprising all genders and ages per 100,000 population worldwide.
CRC is the 2nd most common cancer in Malaysia and the most common in Singapore. The lifetime risk of being diagnosed with colorectal cancer is about 1 in 20 for both sexes in Malaysia. It is most prevalent in men of Chinese ethnicity and meat-eaters. CRC is also the 2nd most common cancer in women. Over 70% of people are diagnosed only in the late stages (3rd or 4th stage), greatly raising the risk of death. Don’t become another statistic!
Signs and Symptoms of Colorectal Cancer

Progression of a Small Polyp to CRC
Almost all colorectal cancers begin as precancerous polyps (abnormal tissue growths) in the colon or rectum. Such polyps can be present in the colon for years before cancer develops [2]. You may not detect any symptoms, especially early on.
If you feel that you may be at risk for CRC, check for these possible signs:
- Changes in bowel movements, including long-standing constipation or diarrhea.
- Feeling like you can’t empty your bowels completely or you urgently need to poop.
- Cramping in your rectum.
- Rectal bleeding.
- Dark patches of blood in or on your stool.
- Long, thin, stringy “pencil stools”.
- Belly discomfort or bloating.
- Fatigue.
- Loss of appetite and weight loss with no clear cause.
- Pelvic pain.
- Anemia (an unusually low number of red blood cells) due to bleeding in your intestines.

High-Risk Groups for CRC are those who are aged 50+, with a history of polyps, and who are heavy meat eaters. Being overweight or obese, physically inactive, a smoker, or a heavy alcohol user also increases the risk of contracting CRC.
However, while colorectal cancer mainly affects those aged 50 and above, Malaysia is seeing a “worrisome” rise in colon cancer incidence among younger adults. This is due primarily to the increased consumption of ultra-processed foods, according to a recent Ministry of Health (MOH) report [3].

What Causes Serious Gut Diseases?
The root cause of gut diseases, including colorectal cancer, is gut dysbiosis or imbalance. This is when an imbalance in our gut microbiota occurs. Pathogenic, bad species like Fusobacterium nucleatum increase, while beneficial bacteria that protect against cancer lessen significantly.

Dysbiosis also often results in chronic inflammation, which is a recognized risk factor for CRC. In addition, gut dysbiosis leads to an altered microbiota composition characterized by an overabundance of harmful bacteria and a severe lack of protective beneficial strains.
How is CRC Diagnosed?

CRC is most commonly detected via a colonoscopy procedure. A long, flexible, and slender tube or scope is attached to a video camera and monitor to view the whole colon and rectum. A doctor may pass surgical tools through the tube to take tissue samples and remove polyps. Due to its invasive nature, many patients dread the discomfort of a colonoscopy. Moreover, no drugs exist to prevent CRC, while current prevention measures, such as avoiding alcohol, eating healthily, quitting smoking, and exercising regularly, are just not effective enough.
Don’t Wait to Protect Your Gut! Lower Your CRC Risk—Naturally and Pain-Free.

Now you need not undergo the inconvenience or stress of an invasive colonoscopy to shield yourself from colorectal cancer. There is a much easier and more effective way to protect yourself!
G-NiiB SMT04 is an award-winning, clinically proven, medical oral probiotic that addresses and treats serious gut health concerns, particularly Irritable Bowel Syndrome (IBS) and CRC. This revolutionary formulation was developed by gastroenterologists who understand the complexities of gut health.

SMT04 leverages advanced shotgun metagenomic techniques to identify, analyze, and target CRC-associated pathogens. This therapeutic probiotic promotes beneficial gut flora to enhance overall gut health, alleviate sensitive gut symptoms, and reduce the risk of serious gastrointestinal diseases.

SMT04 also helps gut health by strengthening the intestinal lining to prevent harmful substances from leaking into the bloodstream. It effectively reduces intestinal permeability (Leaky Gut). SMT04 is safe and effective; no adverse effects have been reported, and it is suitable for long-term use.
There is Power in Precision!
Only SMT04 Targets Exact Strains to Heal Your Gut.

Not all probiotics are created equal. Only SMT04 contains 3 clinically proven probiotic strains developed to combat CRC: B. adolescentis, B. longum, and B. bifidum. It was found that adenoma (non-cancerous tumours) and CRC patients had significantly lower amounts of these 3 strains. The greater the number of these 3 strains in a patient’s gut, the lower the incidence of CRC progression. Together, these 3 strains work synergistically and are highly effective in inhibiting the growth of Fusobacterium nucleatum (Fn), a pathogen that causes CRC.
In addition, SMT04 contains Streptococcus Thermophilus, which helps suppress tumour growth and kill cancer cells. This particular strain was found to be lacking in CRC patients.
SMT04 also contains 4 prebiotic blends to transform your gut health for the better:

- Galacto-oligosaccharides (GOS): Stimulate Bifidobacteria, increasing SCFA production for stronger immunity [4].
- Inulin: Promotes beneficial bacteria growth and reduces inflammation, especially when combined with GOS, for stronger CRC protection [5].
- Polydextrose: Improves gut health, enhances microbial diversity, and regulates blood sugar [6].
- Tara gum: Works with S. thermophilus to strengthen the intestinal barrier [7].
How SMT04 Can Save You Thousands of Ringgit in the Long Run

SMT04 is not just a probiotic- it is an investment in your long-term health. The cost of treating gut issues like IBS/IBD (Inflammatory Bowel Disease) ranges between RM5,000-RM15,000 annually in private healthcare. The cost of treating CRC is between RM100,000-RM300,000 in private hospitals.
In comparison, the cost of SMT04 is just RM200-RM300 per month, which works out to less than RM10 a day- surely a great health investment that will save you a significant amount of money, long term. By investing in SMT04, you can prevent costly medical expenses as it reduces the risk of gut issues and CRC.
Still Unsure if Probiotics Can Really Prevent CRC?
Here’s Concrete Proof That It Does!
In a groundbreaking clinical trial [8], it was proven that SMT04 could effectively reduce CRC-associated bacterial pathogens (Fn, m3, and Ch) after 3 months. SMT04 also successfully alleviated gastrointestinal symptoms in patients who consumed SMT04 for 3 months. Bloating was reduced by 67%, diarrhea by 100%, and constipation by 25%.

SMT04 Works! Proven Results from Clinical Trials

83.3% reduction in CRC/adenoma-related bacteria (Fn, m3, Ch).

42.6% increase in good bacteria (Bifidobacteria).
33.3% decrease in intestinal permeability (reduces leaky gut syndrome).
Start Reaping the Benefits of SMT04’s Proven Triple Action, Today!

✅ Restores gut balance by replenishing specific beneficial strains (Bifidobacterium adolescentis, B. bifidum, B. longum, and S. thermophillus).
✅ Targets harmful pathogens linked to gut diseases. (e.g. Fusobacterium nucleatum [Fn], m3, and Ch).
✅ Leverages G-NiiB’s patented Microencapsulation Technology for maximum colonization and efficacy, backed by real-time clinical trials.
Act Now! Your Gut Can’t Wait!

The threat of contracting CRC is very real indeed. We understand your fears. Fight back with a trusted, Science-backed way and enjoy peace of mind knowing you’re well protected from this deadly cancer. Get your stock of our next-generation SMT04 precision probiotic today at your nearest pharmacy or online at our special price.
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References:
[1] https://www.sciencedirect.com/science/article/abs/pii/S1877782125000153
[2] Are men at higher risk for Colorectal cancer? | Gastroenterologist near me
[3] Malaysia Seeing ‘Worrisome’ Rise In Colorectal Cancer Among Under-50s: MOH Official – CodeBlue
Colorectal Cancer Impacting More Young Malaysians – Cancer Matters
[4] Bruno-Barcena JM. Galacto-oligosaccharides and Colorectal Cancer: Feeding our Intestinal Probiome. J Funct Foods. 2015 Jan;12:92-108.
[5] Qamar TR. Novel Combination of Prebiotics Galacto-Oligosaccharides and Inulin-Inhibited Aberrant Crypt Foci Formation and Biomarkers of Colon Cancer in Wistar Rats. Nutrients. 2016 Aug 1;8(8):465.
[6] do Carmo MM. Polydextrose: Physiological Function, and E”ects on Health. Nutrients. 2016 Sep 8;8(9):553. doi: 10.3390/nu8090553. PMID: 27618093; PMCID: PMC5037538.
[7] Del Piano M. Assessment of the capability of a gelling complex made of tara gum and the exopolysaccharides produced by the microorganism Streptococcus thermophilus ST10 to prospectively restore the gut physiological barrier: a pilot study. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S56-61.
[8] The Effect of a Novel Probiotic Formula (SMT04) in Reducing Colorectal Cancer- Associated Biomarkers.
Jessica YL Ching, Pui Kuan Cheong, Jessie Qiaoyi Liang. The Effect of a Novel Probiotic Formula (SMT04) in Reducing Colorectal Cancer-Associated Biomarkers. J Probiotics and Dietetics 2023. 3(1)08-123(1)08-12.
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